Old friends recall their past relationships and reflect on how women have affected their lives when they gather together in their hometown for a high school reunion. Timothy Hutton, Matt Dillon, Michael Rapaport, Uma Thurman, Martha Plimpton, Mira Sorvino, Lauren Holly, Annabeth Gish, Natalie Portman, Rosie O'Donnell, Noah Emmerich, Max Perlich, Pruitt Taylor Vince, Sam Robards, David Arquette.